Inferring genetic fitness from genomic data
نویسندگان
چکیده
منابع مشابه
Inferring genetic interactions from comparative fitness data
Darwinian fitness is a central concept in evolutionary biology. In practice, however, it is hardly possible to measure fitness for all genotypes in a natural population. Here, we present quantitative tools to make inferences about epistatic gene interactions when the fitness landscape is only incompletely determined due to imprecise measurements or missing observations. We demonstrate that gene...
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2008 i ACKNOWLEDGEMENTS I am greatly indebted to Dr. Sung Wing-Kin for being my supervisor in this project. He has been unyielding in providing me with guidance and inspiration. Our many invaluable discussions helped me significantly to navigate through the research process. I extend my utmost gratitude for his constant encouragement and support. Karuturi Radha Krishna Murthy for the many great...
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High-throughput sequencing based techniques, such as 16S rRNA gene profiling, have the potential to elucidate the complex inner workings of natural microbial communities - be they from the world's oceans or the human gut. A key step in exploring such data is the identification of dependencies between members of these communities, which is commonly achieved by correlation analysis. However, it h...
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The analysis of genetic sequence data collected during disease outbreaks has emerged as a promising new tool for understanding infectious disease dynamics and designing control measures against infectious diseases. Hence, there is a need for statistical methodologies that effectively integrate genetic data with other epidemiological data to perform inference on the underlying disease dynamics. ...
متن کاملInferring genetic regulatory logic from expression data
MOTIVATION High-throughput molecular genetics methods allow the collection of data about the expression of genes at different time points and under different conditions. The challenge is to infer gene regulatory interactions from these data and to get an insight into the mechanisms of genetic regulation. RESULTS We propose a model for genetic regulatory interactions, which has a biologically ...
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ژورنال
عنوان ژورنال: Physical Review E
سال: 2020
ISSN: 2470-0045,2470-0053
DOI: 10.1103/physreve.101.052409